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KMID : 0043320160390020271
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Archives of Pharmacal Research
2016 Volume.39 No. 2 p.271 ~ p.278
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Inhibitory effect of polyozellin on secretory group IIA phospholipase A2
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Ku Sae-Kwang
Yang Eun-Ju
Kang Hye-Jin
Jung Byeong-Jin
Bae Jong-Sup
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Abstract
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The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) is enhanced by development of inflammatory disorders. In this study, sPLA2-IIA expression was induced in the lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells and mice to evaluate the effect of polyozellin. Polyozellin, a major constituent of a Korea edible mushroom Polyozellus multiplex, has been known to exhibit the biological activities such as anti-oxidative and anti-inflammatory effects. Polyozellin remarkably suppressed the LPS-mediated protein expression and activity of sPLA2-IIA via inhibition of phosphorylation of cytosolic phospholipase A2 and extracellular signal-regulated kinase 1/2. These results demonstrated that polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.
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KEYWORD
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Polyozellin, HUVECs, sPLA2-IIA, Inflammation
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